We recommend that you reach out to Dave Myers, the ag agent in the Prince George's County Extension office, as he has expertise in both agronomy and weed science. As a summer annual, Jimsonweed will die on its own this winter (if it hasn't already), so control can focus on preventing seedlings from germinating in spring. Removal of plant parts probably just needs to shield you from sap contact with eyes and from ingesting plant parts, but see if Dave has any particular tips for safety, debris disposal, and effective long-term management.

Miri